Synthetic studies of antitumor macrolide
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Arun K Ghosh; Yong Wang
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Article
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2000
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Elsevier Science
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French
โ 130 KB
A stereoselective synthesis of the C 17 ยฑC 28 segment of the potent antitumor macrolide, laulimalide has been accomplished. The key steps are a ring-closing oleยฎn metathesis to construct the dihydropyran unit, nucleophilic addition of an alkynyl anion to the Weinreb amide, stereoselective reduction