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Synthetic studies on (+)-aplasmomycin. 1. Stereoselective synthesis of the C-12~C-17 segment

โœ Scribed by Tadashi Nakata; Kunio Saito; Takeshi Oishi


Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
222 KB
Volume
27
Category
Article
ISSN
0040-4039

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Synthetic studies of antitumor macrolide
โœ Arun K Ghosh; Yong Wang ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 130 KB

A stereoselective synthesis of the C 17 ยฑC 28 segment of the potent antitumor macrolide, laulimalide has been accomplished. The key steps are a ring-closing oleยฎn metathesis to construct the dihydropyran unit, nucleophilic addition of an alkynyl anion to the Weinreb amide, stereoselective reduction