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Studies on the total synthesis of the macrolide antitumor agent rhizoxin. 2. Synthesis of the C14C26 segment
✍ Scribed by James D. White; Mark A. Holoboski; Neal J. Green
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 170 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Studies on the Total Synthesis of the Macrolide Antitumor Agent Rhizoxin.
- Synthesis of the C14-C26 Segment.
📜 SIMILAR VOLUMES
An asymmetric synthesis of the C3-C13 segment of rhizoxin is described in which the relative stereochemistry of C7 and C8 is established through a chelation-controlled allylation followed by Mitsunobu inversion, and the pyran ring is constructed by a photochemically initiated 6-exo radical cyclizati
A stereocontrolled synthesis of the C 1 C 9 segment of the marine natural product peloruside A is described. The key steps involve Sharpless's catalytic asymmetric dihydroxylation reaction, a chelation-controlled reduction of chiral b-alkoxy ketones to elaborate the syn-1,3-diol functionality and a