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Studies on the total synthesis of the macrolide antitumor agent rhizoxin. 1. Synthesis of the C3C13 segment

✍ Scribed by James D. White; Christine S. Nylund; Neal J. Green

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
196 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

An asymmetric synthesis of the C3-C13 segment of rhizoxin is described in which the relative stereochemistry of C7 and C8 is established through a chelation-controlled allylation followed by Mitsunobu inversion, and the pyran ring is constructed by a photochemically initiated 6-exo radical cyclization.

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