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Total synthesis of the ionophore antibiotic ionomycin. Asymmetric synthesis of the C1-C10 and C11-C16 synthons

✍ Scribed by David A. Evans; Robert L. Dow

Publisher: Elsevier Science
Year: 1986
Tongue: French
Weight: 214 KB
Volume: 27
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(86)80034-x

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✦ Synopsis

Asymmetric synthesis of the synthons 1 and 3 are described. Absolute stereochemical reiationships in these intermediates have been established via chiral enolate and directed hydrogenation processes.

From the standpoint of chemical synthesis, the polyether antibiotics present a formidable chal-

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