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The total synthesis of pamamycin 607. 1. Synthesis of a C1′-C11′ synthon

✍ Scribed by Irene Mavropoulos; Patrick Perlmutter


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
139 KB
Volume
37
Category
Article
ISSN
0040-4039

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The macrodiolide antibiotic pamamycin-607 has been synthesized by coupling of the two hydroxy acid constituents using the Yamaguchi method. While the final lactonization with formation of the ester linkage between C(1) and the C(8%) oxygen proceeded with complete C(2) epimerization, the alternative