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Asymmetric synthesis of the C(1)C(47) backbone of antitumour antibiotic A83586C

✍ Scribed by Karl J Hale; Jiaqiang Cai; Vern M Delisser

Publisher: Elsevier Science
Year: 1996
Tongue: French
Weight: 223 KB
Volume: 37
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)82960-7

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✦ Synopsis

Protected pentapeptide 9 has been converted to hexapeptide 3 and this chemoselectively coupled to activated ester 2 to give 1 after glycal hydration during SiO2 flash chromatography.

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