Synthetic studies on the azinothricin family of antibiotics. 4. Enantioselective synthesis of the northern half of antitumour antibiotics A83586C and citropeptin
โ Scribed by Karl J. Hale; Jiaqiang Cai; Soraya Manaviazar; S. Andrew Peak
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 220 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The tetrasubstituted dehydropiperidine and piperidine cores of the thiostrepton family of peptide antibiotics were synthesized which featured the coupling between the azomethine ylide and the enantiopure sulfinimine, and the subsequent stereoselective reduction of the six-membered imine.
Regiospecific cyclization of the alcohol &into the bicyclo[ 4.2.21 compound g was achieved via selective activation of the secondary methoxy group and subsequent acid treatment. A side-chain was introduced at the bridge-head position, thus making up the bicyclomycin skeleton. Bicyclomycin, which i