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Synthetic studies on the thiostrepton family of peptide antibiotics: synthesis of the tetrasubstituted dehydropiperidine and piperidine cores

✍ Scribed by Syuhei Higashibayashi; Kimiko Hashimoto; Masaya Nakata

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 117 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)02090-1

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✦ Synopsis

The tetrasubstituted dehydropiperidine and piperidine cores of the thiostrepton family of peptide antibiotics were synthesized which featured the coupling between the azomethine ylide and the enantiopure sulfinimine, and the subsequent stereoselective reduction of the six-membered imine.

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