✦ LIBER ✦
Synthetic studies on bicyclomycin I synthesis of 1-allyl and benzoyl-8,10-dimethyl-6-methoxy-5-methylene-8,10-diaza-2-oxabicyclo[4.2.2]Decane-7,9-dione, which have the bicyclo ring system found in antibiotic bicyclomycin
✍ Scribed by Shin-ichi Nakatsuka; Kumi Yoshida; Toshio Goto
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 238 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Regiospecific cyclization of the alcohol &into the bicyclo[ 4.2.21 compound g was achieved via selective activation of the secondary methoxy group and subsequent acid treatment.
A side-chain was introduced at the bridge-head position, thus making up the bicyclomycin skeleton.
Bicyclomycin, which is produced by Streptomyces sapporonensis' and S. aizunensis, 2 possesses unique antibacterial activities.