The novel antifungal karnamicin B, (1), 5-hydroxy-3,4-dimethoxy-2-(2-(4-oxopentyl)-4-thiazolyl}pyridine-6-carboxamide was first synthesized via the formation of partially methylated trihydroxy pyridine by ring-transformation from the corresponding furan derivative and subsequent regioselective intro
✦ LIBER ✦
Total synthesis of the antibiotic polymyxin B1
✍ Scribed by K. Vogler; R. O. Studer; P. Lanz; W. Lergier; Erika Böhni
- Book ID
- 112701340
- Publisher
- Springer
- Year
- 1964
- Tongue
- English
- Weight
- 232 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1420-682X
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Total Synthesis of Antibiotic Karnamicin B1. -The reaction of the furan derivative (I) with bromine in MeOH gives a bromo-methoxyfuran (III) instead of the normal dimethoxyfuran. Successful ring-transformation into the trihydroxy pyridine derivative (V) provides the base for the first total synthes
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