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Total synthesis of prostaglandins. II. Prostaglandin E1

✍ Scribed by Sih, Charles J.; Price, Philip; Sood, Rattan; Salomon, Robert G.; Peruzzotti, George; Casey, Martha

Book ID
121288777
Publisher
American Chemical Society
Year
1972
Tongue
English
Weight
236 KB
Volume
94
Category
Article
ISSN
0002-7863

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πŸ“œ SIMILAR VOLUMES

A biogenetically patterned total synthes
A biogenetically patterned total synthesis of prostaglandin E1
✍ Chisato Sato; Shun'ichi Ikeda; Haruhisa Shirahama; Takeshi Matsumoto πŸ“‚ Article πŸ“… 1982 πŸ› Elsevier Science 🌐 French βš– 231 KB

Methyl ll-tert-butyldimethylsilyloxyeicosa-8~Z),l2~E),l4(E)trienoate was stereoselectively cyclized by treatment with Hg(OCOCF3j2 to give a properly functionalized PG skeleton, which was converted to PGEl in good over all yield.

Total synthesis of prostaglandins. V. A
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We wish to report the synthesis of prostaglandin E2 (PGE2, &) via conjugate addition of the vinyl cupratez, derived from trans-3(E)-(l-ethoxyethoxy)l-iodo-l-octene (3b), to 2-(6-carbomethoxy-~-2-hexenyl)-4(R)-(2-tetrahydropyranyloxy)-2-cyclopenten-l-one (s). We also describe herein a novel synthesis