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A biogenetically patterned total synthesis of prostaglandin E1

✍ Scribed by Chisato Sato; Shun'ichi Ikeda; Haruhisa Shirahama; Takeshi Matsumoto

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 231 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)87271-8

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✦ Synopsis

Methyl ll-tert-butyldimethylsilyloxyeicosa-8~Z),l2~E),l4(E)trienoate was stereoselectively cyclized by treatment with Hg(OCOCF3j2 to give a properly functionalized PG skeleton, which was converted to PGEl in good over all yield.

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