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Total synthesis of (−)-neplanocin A

✍ Scribed by Mu-Ill Lim; Victor E Marquez

Book ID: 104226304
Publisher: Elsevier Science
Year: 1983
Tongue: French
Weight: 228 KB
Volume: 24
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)94140-6

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✦ Synopsis

A total synthesis of (-)-neplanocin A has been accomplished in 15 steps starting from the readily available D-(+)-ribonic acid y-lactone. The neplanocin antibiotics (NPC-A, 6, C, D, and F) were isolated in 1979 from the culture filtrate of ampullariella regularis A11079.2 Of all the active neplanocins, NPC-A (E), demonstrated to have a superior antitumor activity producing a 120% increase of life span (ILS) in mice bearing L1210 leukemia. 3 In view of its chemotherapeutic potential and good

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