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Total Synthesis of (−)-Neplanocin A by Using Lithium Thiolate-Initiated Michael−Aldol Tandem Cyclization Reaction

✍ Scribed by Ono, Masashi; Nishimura, Katsumi; Tsubouchi, Hiroshi; Nagaoka, Yasuo; Tomioka, Kiyoshi


Book ID
120049280
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
147 KB
Volume
66
Category
Article
ISSN
0022-3263

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The reaction of to-oxo-(x,13-unsaturated esters with lithium thiolates afforded the Michael-aldol tandem cyclization products in good to perfect stereoselectivity depending on the nature of thiolates.