𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Total Synthesis of Indole and Dihydroindole Alkaloids. XVIII. Isomers and analogues of vinblastine

✍ Scribed by James P. Kutney; Toshio Honda; Peter M. Kazmaier; Norman J. Lewis; Brian R. Worth

Publisher
John Wiley and Sons
Year
1980
Tongue
German
Weight
590 KB
Volume
63
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The synthesis and conformational analysis of (3′R)‐3‐hydroxyleurosidine (5), (3′S)‐3‐hydroxyleurosidine (10), (3′S)‐3‐acetoxy‐4′‐deoxyleurosidine (15), (3′R)‐3‐acetoxy‐4′‐deoxyleurosidine (23), (3′R)‐3‐acetoxy‐4′‐deoxyvinblastine (16), (3′S)‐3‐acetoxy‐4′‐deoxyleurosidine (28) is discussed.

📜 SIMILAR VOLUMES

Total Synthesis of Indole and Dihydroind
Total Synthesis of Indole and Dihydroindole Alkaloids. XIII. Further Chemistry of Catharanthine
✍ James P. Kutney; Toshio Honda; Alummoottil V. Joshua; Norman G. Lewis; Brian R. 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 German ⚖ 675 KB

## Abstract Further investigations on the chemistry of catharanthine have provided information, valuable in the estimation of reactivity and steric requirements of the skeleton. Specific hydroxylations at C(3), C(4) and C(18) have allowed the preparation of several derivatives including (3R, 4 R)‐3

Total Synthesis of Indole and Dihydroind
Total Synthesis of Indole and Dihydroindole Alkaloids. XV. Further Chemistry of Vindoline
✍ James P. Kutney; Ursula Bunzli-Trepp; Toshio Honda; Junki Katsube; Brian R. Wort 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 German ⚖ 763 KB

## Abstract The general reactivity of various sites in the vindoline series has been investigated. The facility of electrophilic substitution at C(15) and the effect of steric crowding on reactions at C(4) are discussed. At the basic nitrogen sites, oxidations with mercuric acetate and potassium pe

Synthesis of (−)-Hobartine and Related I
Synthesis of (−)-Hobartine and Related Indole Alkaloids
✍ Tamis Darbre; Cornelius Nossbaumer; Hans-Jürg Borschberg 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 German ⚖ 776 KB

## Abstract An improved method for obtaining optically pure (__S__)‐(l‐__p__‐menthen‐8‐yl)amine (**12**) has led to expedient syntheses of two hypothetical biogenetic intermediates on the way to aistoteline (**7**), namely (__S__)‐(__N__)‐(l‐__p__‐menthen‐8‐yl)‐2‐(3‐indolyl)ethylamine (**3**) and (