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Total Synthesis of (+)-Epiquinamide

โœ Scribed by Wijdeven, Marloes A.; Botman, Peter N. M.; Wijtmans, Roel; Schoemaker, Hans E.; Rutjes, Floris P. J. T.; Blaauw, Richard H.


Book ID
121316161
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
76 KB
Volume
7
Category
Article
ISSN
1523-7060

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Total Synthesis of (+)-Epiquinamide.
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The total synthesis of (+)-epiquinamide, a novel quinolizidine alkaloid isolated from the Ecuadoran poison frog, Epipedobates tricolor is described. The key step includes a ring-closing metathesis reaction to construct both the six member rings. D-Mannitol was used as a chiral pool material.

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