Stereoflexible total synthesis of (−)-epiquinamide
✍ Scribed by S. Chandrasekhar; Bibhuti Bhusan Parida; Ch. Rambabu
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 227 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The total synthesis of (+)-epiquinamide, a novel quinolizidine alkaloid isolated from the Ecuadoran poison frog, Epipedobates tricolor is described. The key step includes a ring-closing metathesis reaction to construct both the six member rings. D-Mannitol was used as a chiral pool material.
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First and Stereoflexible Synthesis of Vinylogous Taxol Side Chains. -Starting from readily available chiral starting materials (II) and (VI), stereodefined preparations of the taxol side chains (V) and (IX) are detailed. -(YADAV,
A stereoselective reaction followed by a sequential cyclization route has been used in the divergent synthesis of 1-hydroxyquinolizidione isomers. Sharpless asymmetric dihydroxylation afforded hydroxyl lactone and the following mesylation provided the required precursor for cyclization.