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Asymmetric and diastereodivergent approach to key intermediates for the synthesis of homopumiliotoxin 223G and epiquinamide isomer

✍ Scribed by Le Anh Tuan; Hyeyoung Pyeon; Guncheol Kim

Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 296 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.10.098

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✦ Synopsis

A stereoselective reaction followed by a sequential cyclization route has been used in the divergent synthesis of 1-hydroxyquinolizidione isomers. Sharpless asymmetric dihydroxylation afforded hydroxyl lactone and the following mesylation provided the required precursor for cyclization.

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