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Practical Total Syntheses of Epiquinamide Enantiomers

โœ Scribed by Suyama, Takashi L.; Gerwick, William H.


Book ID
126124480
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
59 KB
Volume
8
Category
Article
ISSN
1523-7060

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The total synthesis of (+)-epiquinamide, a novel quinolizidine alkaloid isolated from the Ecuadoran poison frog, Epipedobates tricolor is described. The key step includes a ring-closing metathesis reaction to construct both the six member rings. D-Mannitol was used as a chiral pool material.