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Total Synthesis of (+)-Dibromophakellin and (+)-Dibromophakellstatin

โœ Scribed by Takuya Imaoka; Takafumi Akimoto; Osamu Iwamoto; Kazuo Nagasawa


Book ID
112006037
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
315 KB
Volume
5
Category
Article
ISSN
1861-4728

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โœ Takuya Imaoka; Osamu Iwamoto; Kei-ichi Noguchi; Kazuo Nagasawa ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 296 KB
Total Synthesis of (+)-Dibromophakellin
โœ Takuya Imaoka; Osamu Iwamoto; Kei-ichi Noguchi; Kazuo Nagasawa ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 296 KB

## Abstract **Two members of a family** of pyrroleโ€“imidazole marine alkaloids, (+)โ€dibromophakellin and the nonnatural congener (+)โ€phakellin, were synthesized enantioselectively from 4โ€hydroxyโ€Lโ€proline. The chiral aminal at C10 was constructed efficiently by means of an Overmanโ€type [3,3] sigmatr