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Total synthesis of deglyco-bleomycin A2

✍ Scribed by Tomohisa Takita; Yoji Umezawa; Sei-ichi Saito; Hajime Morishima; Hamao Umezawa; Yasuhiko Muraoka; Masanobu Suzuki; Masami Otsuka; Susumu Kobayashi; Masaji Ohno

Book ID: 104243636
Publisher: Elsevier Science
Year: 1981
Tongue: French
Weight: 235 KB
Volume: 22
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)92519-5

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✦ Synopsis

Surmnary: Deglyco-bleomycin A2, the aglycon of bleomycin time. A2, has been synthesized for the first Bleomycin (BIM) is an antitumor antibiotic clinically used in the treatment of squamous cell carcinoma and malignant lymphoma. 1 In addition to its medicinal importance, BLM is of great interest because of its complicated structure 2,3 and unique mechanism of action. 3-6 BLM A2 (&-a) is the major component of the BLM clinically used at the present time. Deglyco-BLM A2 (L-b), the

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