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Total synthesis of bleomycin

โœ Scribed by Aoyagi, Yoshiaki; Katano, Kiyoaki; Suguna, Hosbett; Primeau, John; Chang, Li Ho; Hecht, Sidney M.

Book ID
121288773
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
273 KB
Volume
104
Category
Article
ISSN
0002-7863

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Total synthesis of bleomycin A21)
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Bleomycin A2 has been synthesized for the first time. Bleomycin (BLM) is an antitumor antibiotic clinically used in the treatment of squamous cell carcinoma, malignant lymphoma and testis tumors. BLM A2 (Q2), the major component of natural BLMs, consists of a linear hexapeptide named deglyco-BLM A2

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Surmnary: Deglyco-bleomycin A2, the aglycon of bleomycin time. A2, has been synthesized for the first Bleomycin (BIM) is an antitumor antibiotic clinically used in the treatment of squamous cell carcinoma and malignant lymphoma. 1 In addition to its medicinal importance, BLM is of great interest bec

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An improved route to synthesize deglyco-bleomycin A2, the aglycon of bleomycin A2, aiming at the total synthesis of bleomycin is described. The new route is characterized by the stepwise elongation of the amino acid constituents and the use of a thiol ester obtained by aldol condensation. Deglyco-b