Total Synthesis of Bleomycin Group Antibiotics. Total Syntheses of Bleomycin Demethyl A2, Bleomycin A2, and Decarbamoyl Bleomycin Demethyl A2
โ Scribed by Katano, Kiyoaki; An, Haoyun; Aoyagi, Yoshiaki; Overhand, Mark; Sucheck, Steven J.; Stevens, William C.; Hess, Cynthia D.; Zhou, Xiang; Hecht, Sidney M.
- Book ID
- 111682768
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 434 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
Surmnary: Deglyco-bleomycin A2, the aglycon of bleomycin time. A2, has been synthesized for the first Bleomycin (BIM) is an antitumor antibiotic clinically used in the treatment of squamous cell carcinoma and malignant lymphoma. 1 In addition to its medicinal importance, BLM is of great interest bec
An improved route to synthesize deglyco-bleomycin A2, the aglycon of bleomycin A2, aiming at the total synthesis of bleomycin is described. The new route is characterized by the stepwise elongation of the amino acid constituents and the use of a thiol ester obtained by aldol condensation. Deglyco-b