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Total Synthesis of Bleomycin Group Antibiotics. Total Syntheses of Bleomycin Demethyl A2, Bleomycin A2, and Decarbamoyl Bleomycin Demethyl A2

โœ Scribed by Katano, Kiyoaki; An, Haoyun; Aoyagi, Yoshiaki; Overhand, Mark; Sucheck, Steven J.; Stevens, William C.; Hess, Cynthia D.; Zhou, Xiang; Hecht, Sidney M.


Book ID
111682768
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
434 KB
Volume
120
Category
Article
ISSN
0002-7863

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Total synthesis of deglyco-bleomycin A2
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Surmnary: Deglyco-bleomycin A2, the aglycon of bleomycin time. A2, has been synthesized for the first Bleomycin (BIM) is an antitumor antibiotic clinically used in the treatment of squamous cell carcinoma and malignant lymphoma. 1 In addition to its medicinal importance, BLM is of great interest bec

A new synthesis of deglyco-bleomycin A2
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An improved route to synthesize deglyco-bleomycin A2, the aglycon of bleomycin A2, aiming at the total synthesis of bleomycin is described. The new route is characterized by the stepwise elongation of the amino acid constituents and the use of a thiol ester obtained by aldol condensation. Deglyco-b