Total synthesis of (+)-aspergillide C

✍ Scribed by Makoto Kanematsu; Masahiro Yoshida; Kozo Shishido

• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 541 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2011.01.078

✦ Synopsis

The enantioselective total synthesis of aspergillide C, a member of a novel class of 14-membered macrolides isolated from the marine-derived fungus Aspergillus ostianus strain 01F313, has been accomplished employing a highly diastereoselective intramolecular oxy-Michael reaction as the key step.