Total Synthesis of Ascididemin-Type Alkaloids Using Alkyne Building Blocks
β Scribed by Yin, Hao; Shan, Naiyu; Wang, Shaozhong; Yao, Zhu-Jun
- Book ID
- 126759063
- Publisher
- American Chemical Society
- Year
- 2014
- Tongue
- English
- Weight
- 550 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0022-3263
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## Abstract Enantiopure NβsulfinylβΞ΄βaminoβΞ²βketoesters and isoquinolones, prepared from sulfinimines (Nβsulfinyl imines) are a new class of polyfunctionalized chiral building blocks. These building blocks provide easy access to enantiomerically pure, functionalized piperidines and tetrahydroisoqui
Reactions of the dimetalatcd B-carbolme 6, prepared ftom 1-bromo-Rcarbolme (4), witb electrophiles are. key steps in the syntheses of various &carboline alkaloids. Tmnmxtalation of 6 with ZnCl, followed by palladium-catalyzed CTOSS coupling reaction with Z-chlomquinolme gave the alkaloid nitmmarine