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2-Piperidone Type of Chiral Building Block for 3-Piperidinol Alkaloid Synthesis

โœ Scribed by Toyooka, Naoki; Yoshida, Yasuko; Yotsui, Yasuhito; Momose, Takefumi


Book ID
119965474
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
604 KB
Volume
64
Category
Article
ISSN
0022-3263

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Preparation of chiral building blocks fo
โœ Masataka Ihara; Makoto Suzuki; Akihito Hirabayashi; Yuji Tokunaga; Keiichiro Fuk ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 290 KB

Treatment of meso-diols 3 and 6 with CCL and vinyl acetate without solvent produced the AE part of Aconitium alkaloids 2 and 7 in 68% and 75% yields, respectively, with > 96% e.e. Quantitative formations of their MTPA esters 4 and 8 were achieved by reaction with MTPA in the presence of DCC and DMAP