Total Synthesis of Apoptolidin.
β Scribed by Hermut Wehlan; Mario Dauber; M.-Teresa Mujica Fernand; Julia Schuppan; Rainer Mahrwald; Burkhard Ziemer; M.-Elisa Juarez Garcia; Ulrich Koert
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 14 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The total synthesis of apoptolidin A is described employing an early glycosylation strategy. Strategic disconnections were chosen between C11βC12 (crossβcoupling) and C19OβC1 (macrocyclization). The __cis__βselective glycosylation at C9βOH was achieved with the new SIBA protective group