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Total synthesis of 8(S)-, 9(S)-, 11(S)-, and 12(S)-hydroxyeicosatetraenoic acids (HETE) methyl esters

✍ Scribed by Just, George; Wang, Zhi Yuan

Book ID
127178522
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
986 KB
Volume
51
Category
Article
ISSN
0022-3263

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Enantiospecific syntheses of the ZO-and both 19-hydroxy metabolites of 12(S)-HETE were accomplished using readily available, chiral precursors. Recently, a new metabolite of 12(S)-hydroxyeicosatetraenoic (12-HETE) acid (1) was isolated from the coincubation of human platelets and neutrophils with ar