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Total Synthesis and Biological Evaluation of C16 Analogs of (−)-Dictyostatin

✍ Scribed by Jung, Won-Hyuk; Harrison, Cristian; Shin, Youseung; Fournier, Jean-Hugues; Balachandran, Raghavan; Raccor, Brianne S.; Sikorski, Rachel P.; Vogt, Andreas; Curran, Dennis P.; Day, Billy W.


Book ID
127217397
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
385 KB
Volume
50
Category
Article
ISSN
0022-2623

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Total synthesis and biological evaluatio
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A five-step total synthesis of the antibiotic marinopyrrole A (1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogues whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated.