TOP3A, a new partner gene fused to MLL in an adult patient with de novo acute myeloid leukaemia
β Scribed by Charles Herbaux; Stephanie Poulain; Claus Meyer; Rolf Marschalek; Aline Renneville; Jose Fernandes; Olivier Theisen; Sabine Tricot; Marc Simon; Patrick Duthilleul; Agnes Daudignon
- Book ID
- 114714575
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 222 KB
- Volume
- 157
- Category
- Article
- ISSN
- 0007-1048
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The t(9;11) has been described in patients with acute myeloid leukemia (AML), and two genes [AF9 (at 9p21) and FBP17 (at 9q34)] have been cloned as fusion partners of the MLL gene. From an AML-M5 with a t(9;11)(q34;q23), we identified a novel MLL fusion partner, AF9Q34. The AF9Q34 protein shows high
## Abstract We have shown that the __CBL__ gene at 11q23.3, telomeric to __MLL__, was fused to __MLL__ in an adult patient with de novo acute myeloid leukemia (FABβM1). Southern blot analysis indicated that the __MLL__ rearrangement was involved in the chromosomal abnormality. cDNA panhandle polyme
We report on an adult patient with de novo acute myeloid leukemia (AML) with a t(11;22)(q23;q11.2) involving CDCREL1 and MLL genes. Reverse transcriptase (RT)-polymerase chain reaction (PCR) followed by direct sequencing analysis revealed the MLL-CDCREL1 fusion transcript in his leukemic cells. Anal