The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21)
✍ Scribed by Strehl, Sabine; Borkhardt, Arndt; Slany, Robert; Fuchs, Uta E; König, Margit; Haas, Oskar A
- Book ID
- 110067174
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 218 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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## Abstract The mixed lineage leukemia, __MLL__, gene is frequently rearranged in patients with secondary leukemia following treatment with DNA topoisomerase II inhibitors. By FISH and Southern blot analyses we identified a rearrangement in the __MLL__ gene due to a novel t(3;11)(q28;q23) chromosom
We report on an adult patient with de novo acute myeloid leukemia (AML) with a t(11;22)(q23;q11.2) involving CDCREL1 and MLL genes. Reverse transcriptase (RT)-polymerase chain reaction (PCR) followed by direct sequencing analysis revealed the MLL-CDCREL1 fusion transcript in his leukemic cells. Anal