A new case of translocation t(6;11)(q21;q23) in a patient with therapy-related acute myeloblastic leukemia is reported. The translocation results in fusion of the MLL and AF6q21 genes. The breakpoint with AF6q21 is located within the sequences encoding the AF6q21 fork head motif. The similar locatio
✦ LIBER ✦
Partial tandem duplication of MLL gene in acute myeloid leukemia with translocation (11;17)(q23;q12–21)
✍ Scribed by Shuichi Yamamoto; Masanori Nishi; Kazuto Taniguchi; Miyoko Imayoshi; Yoshiyasu Ogata; Manabu Iwanaga; Nana Sakai; Yuhei Hamasaki; Eiichi Ishii
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 114 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0361-8609
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We report on an adult patient with de novo acute myeloid leukemia (AML) with a t(11;22)(q23;q11.2) involving CDCREL1 and MLL genes. Reverse transcriptase (RT)-polymerase chain reaction (PCR) followed by direct sequencing analysis revealed the MLL-CDCREL1 fusion transcript in his leukemic cells. Anal