AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14)
β Scribed by Hayette, S; Tigaud, I; Vanier, A; Martel, S; Corbo, L; Charrin, C; Beillard, E; Deleage, G; Magaud, J P; Rimokh, R
- Book ID
- 110064105
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 207 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0950-9232
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## Abstract We report a novel __MLL__βassociated chromosome translocation t(11;14)(q23;q24) in a child who showed signs of acute undifferentiated leukemia 3 years after intensive chemotherapy that included the topoisomeraseβII inhibitor VP 16. Screening of a cDNA library of the patient's leukemic c
## Abstract The mixed lineage leukemia, __MLL__, gene is frequently rearranged in patients with secondary leukemia following treatment with DNA topoisomerase II inhibitors. By FISH and Southern blot analyses we identified a rearrangement in the __MLL__ gene due to a novel t(3;11)(q28;q23) chromosom