## Abstract The mixed lineage leukemia, __MLL__, gene is frequently rearranged in patients with secondary leukemia following treatment with DNA topoisomerase II inhibitors. By FISH and Southern blot analyses we identified a rearrangement in the __MLL__ gene due to a novel t(3;11)(q28;q23) chromosom
Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)
β Scribed by Borkhardt, Arndt; Repp, Reinald; Haas, Oskar A; Leis, Thomas; Harbott, Jochen; Kreuder, Joachim; Hammermann, Jutta; Henn, Traudl; Lampert, Fritz
- Book ID
- 110060479
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 559 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0950-9232
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## Abstract We report a novel __MLL__βassociated chromosome translocation t(11;14)(q23;q24) in a child who showed signs of acute undifferentiated leukemia 3 years after intensive chemotherapy that included the topoisomeraseβII inhibitor VP 16. Screening of a cDNA library of the patient's leukemic c
We report on an adult patient with de novo acute myeloid leukemia (AML) with a t(11;22)(q23;q11.2) involving CDCREL1 and MLL genes. Reverse transcriptase (RT)-polymerase chain reaction (PCR) followed by direct sequencing analysis revealed the MLL-CDCREL1 fusion transcript in his leukemic cells. Anal