FLNA, a new partner gene fused to MLL in a patient with acute myelomonoblastic leukaemia
✍ Scribed by Etienne De Braekeleer; Nathalie Douet-Guilbert; Frédéric Morel; Marie-Josée Le Bris; Claus Meyer; Rolf Marschalek; Claude Férec; Marc De Braekeleer
- Book ID
- 108676428
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 242 KB
- Volume
- 146
- Category
- Article
- ISSN
- 0007-1048
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## Abstract We report a novel __MLL__‐associated chromosome translocation t(11;14)(q23;q24) in a child who showed signs of acute undifferentiated leukemia 3 years after intensive chemotherapy that included the topoisomerase‐II inhibitor VP 16. Screening of a cDNA library of the patient's leukemic c
## Abstract The mixed lineage leukemia, __MLL__, gene is frequently rearranged in patients with secondary leukemia following treatment with DNA topoisomerase II inhibitors. By FISH and Southern blot analyses we identified a rearrangement in the __MLL__ gene due to a novel t(3;11)(q28;q23) chromosom
## Abstract We have shown that the __EB1__ (__MAPRE1__) gene, at 20q11.2, is fused to __MLL__ in an adult patient with pro‐B acute lymphoblastic leukemia. Southern blot analysis indicated that a rearrangement of the __MLL__ gene was involved in the chromosomal abnormality. cDNA panhandle polymerase