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Thyroid Hormones Decrease Plasma 1α,25-Dihydroxyvitamin D Levels Through Transcriptional Repression of the Renal 25-Hydroxyvitamin D 3 1α-Hydroxylase Gene ( CYP27B1 )

✍ Scribed by Kozai, Mina; Yamamoto, Hironori; Ishiguro, Mariko; Harada, Nagakatsu; Masuda, Masashi; Kagawa, Tomohiro; Takei, Yuichiro; Otani, Ayako; Nakahashi, Otoki; Ikeda, Shoko; Taketani, Yutaka; Takeyama, Ken-ichi; Kato, Shigeaki; Takeda, Eiji

Book ID
120066327
Publisher
Endocrine Society
Year
2013
Tongue
English
Weight
523 KB
Volume
154
Category
Article
ISSN
0013-7227

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## Abstract Mutations in the human 25‐hydroxyvitamin‐D~3~‐1α‐hydroxylase (CYP27B1) gene cause pseudo vitamin D deficiency rickets (PDDR). The kidney is the main site of expression of the __CYP27B1__ gene, but expression has been documented in other cell types, including chondrocytes. We engineered