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Regulation of 25-Hydroxyvitamin D3 1α-Hydroxylase Gene Expression by Parathyroid Hormone and 1,25-Dihydroxyvitamin D3

✍ Scribed by Holly L. Brenza; Hector F. DeLuca

Book ID
115568374
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
363 KB
Volume
381
Category
Article
ISSN
0003-9861

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## Abstract The 25‐hydroxyvitamin D~3~‐24‐hydroxylase mRNA is tightly and reciprocally regulated by 1,25‐dihydroxyvitamin D~3~ (1,25(OH)~2~D~3~) and parathyroid hormone (PTH). The upregulation of the 24‐hydroxylase by 1,25(OH)~2~D~3~ is well established and occurs at the transcriptional level throu