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Thymidylate synthase and dihydropyrimidine dehydroge-nase expression in stage II and III colorectal cancer patients receiving adjuvant 5-fluorouracil

✍ Scribed by Kornmann, M. (author);Link, K. (author);Sander, S. (author);Kron, M. (author);Sträter, J. (author);Schwabe, W. (author);Häussler, P. (author);Behnke, D. (author);Beger, H. (author)

Book ID
123106394
Publisher
Elsevier BV
Year
2001
Tongue
English
Weight
357 KB
Volume
37
Category
Article
ISSN
0959-8049

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## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30