Thermodynamic investigations of interaction of aqueous solutions of 2′,3′-dideoxyinosine and 2′,3′-dideoxyadenosine with glycyl-glycine
✍ Scribed by B. Golankiewicz; A. Zielenkiewicz; J. Zeidler; W. Zielenkiewicz
- Book ID
- 110552386
- Publisher
- Springer Netherlands
- Year
- 1995
- Tongue
- English
- Weight
- 246 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0022-5215
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## Abstract 2′,3′‐Dideoxyinosine‐^13^C~5~ (ddI‐^13^C~5~) and the related 2′,3′‐dideoxyadenosine‐^13^C~5~ (ddA‐^13^C~5~) were prepared from (S)‐5‐[^13^C~5~]2,3‐dideoxyribonolactone 1. From a batch of this starting material ddI‐^13^C~5~ was made in 27% overall yield in seven steps and ddA‐^13^C~5~ in
NMR chemical shifts and one-bond ' 3C-1 H couplings are reported for B'azido-3'-deoxythymidine, 2',3'-dideoxyadenosine, 2',3'-dideoxycytidine and 2 ' 3dideoxyinosine. Unambiguous assignments were made on the basis of results from 2D INADEQUATE experiments to establish the carbon-carbon connectivitie