Comparative pharmacokinetics of new anti-HIV agents: 2', 3'-dideoxyadenosine and 2', 3'-dideoxyinosine
β Scribed by John W. Russell; Lewis J. Klunk
- Book ID
- 115780900
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 299 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0006-2952
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## Abstract 2β²,3β²βDideoxyinosineβ^13^C~5~ (ddIβ^13^C~5~) and the related 2β²,3β²βdideoxyadenosineβ^13^C~5~ (ddAβ^13^C~5~) were prepared from (S)β5β[^13^C~5~]2,3βdideoxyribonolactone 1. From a batch of this starting material ddIβ^13^C~5~ was made in 27% overall yield in seven steps and ddAβ^13^C~5~ in
NMR chemical shifts and one-bond ' 3C-1 H couplings are reported for B'azido-3'-deoxythymidine, 2',3'-dideoxyadenosine, 2',3'-dideoxycytidine and 2 ' 3dideoxyinosine. Unambiguous assignments were made on the basis of results from 2D INADEQUATE experiments to establish the carbon-carbon connectivitie