Theoretical investigations on the formation of nitrobenzanthrone-DNA Adducts
✍ Scribed by Arlt, Volker M.; Phillips, David H.; Reynisson, Jóhannes
- Book ID
- 118203255
- Publisher
- Royal Society of Chemistry
- Year
- 2011
- Tongue
- English
- Weight
- 378 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1477-0520
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## Abstract 3‐Nitrobenzanthrone (3‐NBA) is an environmental pollutant and suspected human carcinogen found in emissions from diesel and gasoline engines and on the surface of ambient air particulate matter; human exposure to 3‐NBA is likely to occur primarily via the respiratory tract. In our study
Diesel exhaust is known to induce tumors in animals and is suspected of being carcinogenic in humans. Of the compounds found in diesel exhaust and in airborne particulate matter, 3-nitrobenzanthrone (3-NBA), is a particularly powerful mutagen. We investigated the capacity of 3-NBA to form DNA adduct