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Theoretical investigations on the formation of nitrobenzanthrone-DNA Adducts

✍ Scribed by Arlt, Volker M.; Phillips, David H.; Reynisson, Jóhannes


Book ID
118203255
Publisher
Royal Society of Chemistry
Year
2011
Tongue
English
Weight
378 KB
Volume
9
Category
Article
ISSN
1477-0520

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## Abstract 3‐Nitrobenzanthrone (3‐NBA) is an environmental pollutant and suspected human carcinogen found in emissions from diesel and gasoline engines and on the surface of ambient air particulate matter; human exposure to 3‐NBA is likely to occur primarily via the respiratory tract. In our study

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Diesel exhaust is known to induce tumors in animals and is suspected of being carcinogenic in humans. Of the compounds found in diesel exhaust and in airborne particulate matter, 3-nitrobenzanthrone (3-NBA), is a particularly powerful mutagen. We investigated the capacity of 3-NBA to form DNA adduct