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DNA adduct formation by the ubiquitous environmental pollutant 3-nitrobenzanthrone and its metabolites in rats

✍ Scribed by Volker M Arlt; Bernd L Sorg; Martin Osborne; Alan Hewer; Albrecht Seidel; Heinz H Schmeiser; David H Phillips

Book ID
117053017
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
458 KB
Volume
300
Category
Article
ISSN
0006-291X

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Diesel exhaust is known to induce tumors in animals and is suspected of being carcinogenic in humans. Of the compounds found in diesel exhaust and in airborne particulate matter, 3-nitrobenzanthrone (3-NBA), is a particularly powerful mutagen. We investigated the capacity of 3-NBA to form DNA adduct

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## Abstract 3‐nitrobenzanthrone (3‐NBA) is an extremely potent mutagen in the Salmonella reversion assay and a suspected human carcinogen identified in diesel exhaust and in ambient airborne particulate matter. To evaluate the in vivo mutagenicity of 3‐NBA, we analyzed the mutant frequency (MF) in

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DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone after intratracheal instillation in rats
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## Abstract 3‐Nitrobenzanthrone (3‐NBA) is an environmental pollutant and suspected human carcinogen found in emissions from diesel and gasoline engines and on the surface of ambient air particulate matter; human exposure to 3‐NBA is likely to occur primarily via the respiratory tract. In our study