Theoretical investigations of the structure of potential inhibitors of the enzyme glyoxalase-I
β Scribed by Colin Thomson; Richard Brandt
- Book ID
- 104581122
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 707 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0020-7608
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A stereoselective, chiral synthesis of the glyoxalase I inhibitor 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6trihydroxycyclohex-2-enone 1 (COTC) from a simple derivative of (-)-quinic acid is described.
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The phenotypes of glyoxalase I (GLO) were determined in a random population from Hessen (Germany) by high-voltage agarose gel electrophoresis. The gene frequencies in 1150 unrelated individuals were 0.4391 for GLO1 and 0.5609 fro GLO2. Rare phenotypes were not observed. The segregation of phenotypes