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A new synthesis of the glyoxalase-I inhibitor COTC

✍ Scribed by C.Frederick M Huntley; Harold B Wood; Bruce Ganem

Book ID
104210008
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
97 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

A stereoselective, chiral synthesis of the glyoxalase I inhibitor 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6trihydroxycyclohex-2-enone 1 (COTC) from a simple derivative of (-)-quinic acid is described.

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