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Total synthesis of a glyoxalase I inhibitor and its precursor, (−)-KD16-U1

✍ Scribed by Kuniaki Tatsuta; Shohei Yasuda; Nobuyuki Araki; Masaaki Takahashi; Yuko Kamiya

Book ID
104258505
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
143 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A glyoxalase I inhibitor and (-)-KD16-UI have been.synthesized from D-ribonic acid ylactone through SnCl4-promoted cyclization of a phenylsulfonyi enol silyl ether and regioselective introduction ofa hydroxymethyi group.

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Synthesis of a Glyoxalase I Inhibitor fr
Synthesis of a Glyoxalase I Inhibitor from Streptomyces griseosporeus NIIDAet OGASAWARA
✍ Sohail Mirza; Louis-Pierre Molleyres; Andrea Vasella 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 German ⚖ 638 KB

## Abstract The pseudolactones **6** and **12** were prepared in a straightforward way from methyl α‐D‐glucopyranoside and methyl α‐D‐mannopyranoside, respectively. The pseudolactone **6** reacted with __tert__‐butyl lithioacetate to give the protected, trihydroxylated cyclohexenone carboxylate **7