𝔖 Bobbio Scriptorium
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Potential transition-state inhibitors of glyoxalase. I

✍ Scribed by Richard B. Brandt; Mark E. Brandt; Michael E. April; Colin Thomson


Book ID
104580779
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
428 KB
Volume
22
Category
Article
ISSN
0020-7608

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πŸ“œ SIMILAR VOLUMES


A new synthesis of the glyoxalase-I inhi
✍ C.Frederick M Huntley; Harold B Wood; Bruce Ganem πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 97 KB

A stereoselective, chiral synthesis of the glyoxalase I inhibitor 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6trihydroxycyclohex-2-enone 1 (COTC) from a simple derivative of (-)-quinic acid is described.

Synthesis of a Glyoxalase I Inhibitor fr
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## Abstract The pseudolactones **6** and **12** were prepared in a straightforward way from methyl α‐D‐glucopyranoside and methyl α‐D‐mannopyranoside, respectively. The pseudolactone **6** reacted with __tert__‐butyl lithioacetate to give the protected, trihydroxylated cyclohexenone carboxylate **7