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α-Aminocyclopropanone hydrates: potential transition-state analog inhibitors of serine proteases

✍ Scribed by Eric Doris; Alain Wagner; Charles Mioskowski

Book ID: 104230468
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 61 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00397-5

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✦ Synopsis

The synthesis of two a-aminocyclopropanone hydrates is reported. These synthons could find biological applications by acting as transition-state analog inhibitors of hydrolytic enzymes, such as serine proteases.

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