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The Use of Polyphosphoric Acid in the Synthesis of 2-Aryl- and 2-Alkyl-substituted Benzimidazoles, Benzoxazoles and Benzothiazoles 1

โœ Scribed by Hein, D. W.; Alheim, R. J.; Leavitt, J. J.


Book ID
118004251
Publisher
American Chemical Society
Year
1957
Tongue
English
Weight
413 KB
Volume
79
Category
Article
ISSN
0002-7863

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The synthesis of benzoxazoles and benzimidazoles is accomplished by treating N,Odiacylated 2-aminophenols or NWdiacylated 1,2-phenylenediamines with p-toluenesulfonic acid under reflux in xylenes or toluene. These reactions are operationally simple and proceed in excellent yield.