The para-Toluenesulfonic Acid-Promoted Synthesis of 2-Substituted Benzoxazoles and Benzimidazoles from Diacylated Precursors.

✍ Scribed by Mark R. DeLuca; Sean M. Kerwin

• Book ID: 104207392
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 445 KB
• Volume: 53
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(96)01009-5

✦ Synopsis

The synthesis of benzoxazoles and benzimidazoles is accomplished by treating N,Odiacylated 2-aminophenols or NWdiacylated 1,2-phenylenediamines with p-toluenesulfonic acid under reflux in xylenes or toluene. These reactions are operationally simple and proceed in excellent yield.