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The use of isotope effects to determine enzyme mechanisms

✍ Scribed by W.W. Cleland

Book ID
116177142
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
358 KB
Volume
433
Category
Article
ISSN
0003-9861

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Use of isotope effects to determine enzy
Use of isotope effects to determine enzyme mechanisms
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## Abstract Isotope effects are a powerful tool for determining the mechanisms of enzymatic reactions. Methods for measurement of isotope effects are reviewed and the equations that describe observed isotope effects and permit determination of intrinsic isotope effects on the isotope‐sensitive step

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✍ Richard L. Schowen πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 French βš– 339 KB

## Abstract The basic principles and illustrative applications to enzyme mechanisms of solvent isotope effects, with emphasis on the use of rate measurements in mixtures of protium and deuterium oxides (β€˜proton inventories’), are reviewed over a period slightly shorter than the history of this Jour